Interventions

  • name effect species mean median maximum
    his-5 RNAi Knockdown of his-5 via RNAi started after the animal reached the late L4 stage increase or decreases lifespan by 2 and 3%, respectively [22103665].
    kat-1 RNAi Knockdown of kat-1 via RNAi started after the animal reached the late L4 stage has no significant effect on mean lifespan [22103665].
    CG11015 RNAi Under rich nutritional conditions lifespan of CG11015 RNAi treated animals is indistinguishable from that of controls, while upon DR, lifespan extension is diminished in males and females [19804760].
    C33H5.18 RNAi RNA interference of C33H5.18 decreases median lifespan by 44% in wild type animals, 77% in a daf-2 background and 14% in daf-2/daf-16 double mutants [18006689]. -44
    YHB1 deletion Deleting YHB1 partially abolished DR-induced replicative lifespan extension, whereas deleting SFA1 alone had no effect. sfa1;yhb1 double mutant cancels out the ability of moderate DR to extend replicative lifespan, but not chronological lifespan. Yhb1 and Sfa1 may play redundant roles [21584246]. Yeast
    grs-1 RNAi grs-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    F38E11.5 RNAi F38E11.5 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    F54D5.11 RNAi F54D5.11 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    rpn-7 RNAi rpn-7 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    par-6 RNAi par-6 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    lys-1 RNAi lys-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    ndc-80 RNAi ndc-80 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    let-92 RNAi let-92 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    his-2 RNAi his-2 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    gsk-3 RNAi gsk-3 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    F16D3.4 RNAi F16D3.4 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    eif-3.E RNAi eif-3.E RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    rsp-8 RNAi rsp-8 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    B0393.6 RNAi B0393.6 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    T04A8.11 RNAi T04A8.11 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    aph-2 RNAi aph-2 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    cdk-1 RNAi cdk-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    dpy-22 RNAi dpy-22 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    evl-20 RNAi evl-20 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    pat-2 RNAi pat-2 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
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    • 25 of 559 interventions
    Interventions are an extension of GenAge and GenDR.