| his-5 RNAi | Knockdown of his-5 via RNAi started after the animal reached the late L4 stage increase or decreases lifespan by 2 and 3%, respectively [22103665]. | — | — | — | — |
| kat-1 RNAi | Knockdown of kat-1 via RNAi started after the animal reached the late L4 stage has no significant effect on mean lifespan [22103665]. | — | — | — | — |
| daf-28 mutation | Semi-dominant mutation in daf-28 increases lifespan by 10-15% [8807293]. The daf-28 mutant is dauer constitutive [8005442]. | — | +10 to +15 | — | — |
| CG11015 RNAi | Under rich nutritional conditions lifespan of CG11015 RNAi treated animals is indistinguishable from that of controls, while upon DR, lifespan extension is diminished in males and females [19804760]. | — | — | — | — |
| C33H5.18 RNAi | RNA interference of C33H5.18 decreases median lifespan by 44% in wild type animals, 77% in a daf-2 background and 14% in daf-2/daf-16 double mutants [18006689]. | — | — | -44 | — |
| CDC6 mutation | The CDC6-1 conditional allele results in an approximately 20% increase in mean replicative life span. This allele is defective for replicative initiation form the rDNA ARS at 27 degree Celsius, resulting in a reduced rate of extrachromosomal rDNA circle accumulation [9428525]. The cdc6-1 allele results in genomic instability at the permissive temperature [8552037]. | Yeast | +20 | — | — |
| Transient CDC7 inactivation | Transient inactivation of CDC7 results in a shortened replicative lifespan [2698814]. | Yeast | — | — | — |
| SOD2 deletion | SOD2 deletion decreases replicative lifespan by 72% [17460215]. SOD2 deletion decreases chronological lifespan [21076178]. Deletion of SOD2 decreases chronological lifespan in wild-type and abolishes chronological lifespan extension in sch9Delta mutants as well as decreases chronological lifespan in cyr1:mTn mutants [12586694].
SOD2 deletion mutants are hypersensitive to oxygen and grow poorly in ethanol [10222047]. | Yeast | -72 | — | — |
| FKH1 FKH2 deletion | Deletion of FKH1 or FKH2 has no effect on neither replicative, nor chronological lifespan [18225956]. Deletion of both FKH1 and FKH2 reduces mean chronological lifespan by 50% and abrogates lifespan extension and increased stress resistance conferred from water starvation (extreme DR). Modest increase in FKH1 or FKH2 expression results in a slight increased chronological and replicative lifespan as well as stress resistance [22438832]. | Yeast | — | — | — |
| GIS1 deletion | Deletion of GIS1 increases replicative lifespan by 25% in the alpha strain [19030232] and causes major although not complete reversion of chronological lifespan extension by 0.5% glucose restriction [18225956]. | Yeast | — | — | — |
| SCH9 Transposition | Transposon-mediated mutagenesis of SCH9, which encodes for a serine threonine kinase homologous to Akt/PKB, increases resistance to oxidants and thermal stress as well as extends chronological lifespan by 30% [11292860]. | Yeast | +30 | — | — |
| FRE6 deletion | FRE6 deletion increases mean replicative lifespan by 14% and cancels out the lifespan extending effect of DR [22912585]. | Yeast | +14 | — | -2 |
| grs-1 RNAi | grs-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| F38E11.5 RNAi | F38E11.5 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| F54D5.11 RNAi | F54D5.11 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| rpn-7 RNAi | rpn-7 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| par-6 RNAi | par-6 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| lys-1 RNAi | lys-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| ndc-80 RNAi | ndc-80 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| let-92 RNAi | let-92 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| his-2 RNAi | his-2 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| gsk-3 RNAi | gsk-3 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| F16D3.4 RNAi | F16D3.4 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| eif-3.E RNAi | eif-3.E RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| rsp-8 RNAi | rsp-8 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
GenAge
GenDR
