Interventions

  • Species: + -
  • name effect species mean median maximum
    aakb-1 RNAi RNA interference of aakb-1 results in decreased lifespan and earlier accumulation of lipofuscin [16673436]. Worm
    aakb-2 RNAi RNA interference of aakb-2 results in decreased lifespan and earlier accumulation of lipofuscin [16673436]. Worm
    aat-8 RNAi RNA interference of aat-8 increases mean lifespan by 30% [17608836]. Worm +30
    abce-1 RNAi abce-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    abcx-1 RNAi RNA interferenceof abcx-1 in adulthood extends mean lifespan by 16% [17521386]. Worm +16
    abi-1 RNAi abi-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    abs-2 RNAi RNA interference of abs-2 leads to lifespan extension [16103914]. Worm
    acdh-1 RNAi RNAi knockdown of acdh-1 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan [22810224]. Worm
    acdh-10 RNAi Kncockdown of acdh-10 via RNAi started after the animal reached the late L4 stage increases mean lifespan by 8% significantly and by 3 non-significantly [22103665]. Worm
    acdh-12 RNAi Knockdown of acdh-12 via RNAi started after the animal reached the late L4 stage has no significant effect on mean lifespan [22103665]. Worm
    acdh-12 RNAi RNA interference of acdh-12 starting at hatching or only during the adulthood significantly decreases eat-2 lifespan without affecting the lifespan of wild-type [22810224]. Worm
    acdh-3 RNAi Knockdown of acdh-3 via RNAi started after the animal reached the late L4 stage has no significant effect on mean lifespan [22103665]. Worm
    acl-11 RNAi RNA interference of acl-11 leads to lifespan extension [12447374]. Worm
    aco-2 RNAi Knockdown of aco-2 via RNAi started after the animal reaches the L4 stage extends mean and maximum lifespan by 9-14% and 9%, respectively [22103665]. Worm +9 to +14 +9
    acs-4 RNAi Knockdown of acs-4 via RNAi started after the animal reached the late L4 stage appeared not significant affect on lifespan (although there was a slight non-significant increase by 5% in mean lifespan). However the same study found also a significant increase in mean lifespan by 6-9% in further experiments [22103665]. Worm +5 to 9%
    acs-5 RNAi RNA interference of acs-5 increases mean lifespan by 52% [17608836]. Worm +52
    act-4 RNAi Knockdown of act-4 started after the animal reached the late L4 stage decreases mean lifespan by 28% [22103665]. Worm
    agmo-1 RNAi RNA interference of agmo-1 decreases median lifespan by 30% in wild type animals and 60% in daf-2 mutants [18006689]. Worm -30
    ain-1 RNAi RNA interference of ain-1 decreases median lifespan by 10% in wild type animals, 20% in a daf-2 background and 44% in daf-2/daf-16 double mutants [18006689]. Worm -10
    alg-1 RNAi Adult-specific knockdown of the C. elegans argonaute-like gene 1 *alg-1* results in shortened lifespan with a reduction in the mean and maximum lifespan by 9 - 16% and 14%, respectively [21810936]. Worm -9.6 to -16.1 -13.7
    alg-2 RNAi RNA interference of alg-2 decreases median lifespan by 24% in wild type animals and 50% in a daf-2 background [18006689]. Worm -24
    amt-2 RNAi RNA interference of amt-2 increases mean lifespan by 20% [17608836]. Worm -20
    ant-1.1 RNAi RNA interference of ant-1.1 increases mean lifespan by 40% [17608836]. Worm +40
    aph-2 RNAi aph-2 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    apr-1 RNAi apr-1 RNAi in the adulthood extends the lifespan [99999999]. Worm
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    • 25 of 530 interventions
    Interventions are an extension of GenAge and GenDR.