Interventions

  • Species: + -
  • name effect species mean median maximum
    (-)-epicatechin treatment Treatment with (-)-epidcatechin do no extend lifespan [20717869]. Worm
    272N18 Treatment 272N18 (3-(3-nitrophenyl)-11-phenyl-2,3,4,5,10,11-hexohydro-1H-dibenzo[b,e] [1,4]diazepin-1-one dihdrochloride) increases lifespan by 20%, bears a structural resemblance to certain human antidepressants that affect signalling by the neurotransmitter serotonin. Worm
    aak-1 mutation aak-1 does not appear to be required for the control of lifespan [15574588]. Worm
    aak-2 constitutive active mutation A constitutive active mutation of aak-2 is sufficient to cause increase stress resistance as well as to significantly extend lifespan. Both increased stress resistance and extended lifespan is reverted in daf-16 knockdown by RNAi [17900900]. Worm
    aak-2 mutation aak-2(ok524) knockout mutants have a 12% and 18% shorter mean and maximum lifespan, respectively as well as faster age-dependent accumulation of a lipofuscin-like fluorescent pigment in the intestine [15574588]. aak-2 mutation suppresses lifespan extension and delay of the decline in locomotor activity resulting from sDR [17900900]. aak-2 mutation cancels out the lifespan extension effect of sDR and PD, regardless of the concentration of bacteria or peptones. bDR significantly extends lifespan of aak-2 mutants, but to lesser extent than that of wild-type. eat-2 mutation extends the lifespan of aak-2 mutants to the same extent than that of wild-type. Resveratrol does not increase lifespan of aak-2 mutants [19239417]. daf-2(m577);aak-2(ok524) double mutant has a lifespan that is indistinguishable from those of aak-2(ok524) single mutant [15574588]. Worm -12 -18
    aak-2 overexpression Transgenic animals with a higher aak-2 gene dose live on average 13% longer with a maximum lifespan extension on up to 25% [15574588]. Worm +13 +25
    aakb-1 RNAi RNA interference of aakb-1 results in decreased lifespan and earlier accumulation of lipofuscin [16673436]. Worm
    aakb-2 RNAi RNA interference of aakb-2 results in decreased lifespan and earlier accumulation of lipofuscin [16673436]. Worm
    aakg-2 overexpression Overexpression of aakg-2 extends mean, median, and maximum lifespan by 47, 45, and 35% [22737090]. Worm +47 +45 +35
    aat-8 RNAi RNA interference of aat-8 increases mean lifespan by 30% [17608836]. Worm +30
    abce-1 RNAi abce-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    abcx-1 RNAi RNA interferenceof abcx-1 in adulthood extends mean lifespan by 16% [17521386]. Worm +16
    abi-1 RNAi abi-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    abs-2 RNAi RNA interference of abs-2 leads to lifespan extension [16103914]. Worm
    abu-11 overexpression Overexpression of abu-11 extends mean lifespan by 9% to 28% [16256736]. Worm +9 to +28
    acdh-1 RNAi RNAi knockdown of acdh-1 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan [22810224]. Worm
    acdh-10 RNAi Kncockdown of acdh-10 via RNAi started after the animal reached the late L4 stage increases mean lifespan by 8% significantly and by 3 non-significantly [22103665]. Worm
    acdh-12 RNAi Knockdown of acdh-12 via RNAi started after the animal reached the late L4 stage has no significant effect on mean lifespan [22103665]. Worm
    acdh-12 RNAi RNA interference of acdh-12 starting at hatching or only during the adulthood significantly decreases eat-2 lifespan without affecting the lifespan of wild-type [22810224]. Worm
    acdh-3 RNAi Knockdown of acdh-3 via RNAi started after the animal reached the late L4 stage has no significant effect on mean lifespan [22103665]. Worm
    acl-11 RNAi RNA interference of acl-11 leads to lifespan extension [12447374]. Worm
    aco-2 RNAi Knockdown of aco-2 via RNAi started after the animal reaches the L4 stage extends mean and maximum lifespan by 9-14% and 9%, respectively [22103665]. Worm +9 to +14 +9
    aco-2 RNAi RNA interference of aco-2 leads to lifespan extension [15998808]. Worm
    acs-4 RNAi Knockdown of acs-4 via RNAi started after the animal reached the late L4 stage appeared not significant affect on lifespan (although there was a slight non-significant increase by 5% in mean lifespan). However the same study found also a significant increase in mean lifespan by 6-9% in further experiments [22103665]. Worm +5 to 9%
    acs-5 RNAi RNA interference of acs-5 increases mean lifespan by 52% [17608836]. Worm +52
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    • 25 of 795 interventions
    Interventions are an extension of GenAge and GenDR.