Interventions

  • name effect species mean median maximum
    CIT2 overexpression Overexpression of CIT2 has no effect on replicative lifespan [10224252]. Yeast
    CKIepsilon mutation A mutation in CKIepsilon called tau, if homozygous, shortens the circadian period (by 20%), increases metabolic rate (by 20%), and increases lifespan by 14-16% under conditions of constant darkness [12054192]. Male and female wild-type hamsters are heavier than homozygous mutants throughout the entire lifespan, and heterozygous mutants have intermediate weight [12054192]. Hamster +14 to +16
    clk-1 overexpression Overexpression of clk-1 shortens lifespan and is associated with increased mitochondrial activity [10202142]. Worm
    clk-1 overexpression Overexpression of clk-1 shortens lifespan and is associated with increased mitochondrial activity [10202142]. Worm
    CLN3 overexpression Overexpression shortens chronological lifespan together with age-dependent increases in genome instability and apoptosis. While around 80% of wild-type cells are alive almost non CLN3 overexpressers are alive (under condition that avoids adaptive regrowth) [17710147]. Yeast
    Constitutive active S6k overexpression Overexpression of a constitutively active form of S6k (alias dS6K) decreases mean lifespan by 34% at 29°C [15186745]. Fly -34
    Constitutive miR-277 expression Constitutive miR-277 expression shortens lifespan and synthetically lethal with reduced insulin signaling, indicating that metabolic control underlies this phenotype [23669073]. Fly
    Coq7 overexpression Transgenic overexpression of mouse Coq7 reverts the extended lifespan of clk-1 mutants [11511092]. Worm
    cst-1 overexpression Overexpression of cst-1 extends lifespan and delays aging in a daf-16-dependent manner [16751106]. Worm
    CTA1 overexpression CTA1 overexpression partially suppresses the shortened chronological lifespan by ISC1 mutation [21707788]. Yeast
    cup-4 overexpression cup-4 overexpession reduces oxidative stress resistance and shortens lifespan of wild-type under AL [19783783]. Worm
    daf-16 overexpression Overexpression of wild-type DAF-16 modestly increases lifespan by 20% [11747825]. Worm +20
    daf-18 overexpression Overexpression increases adult lifespan in individual tissues [16153634]. Worm
    DNApol-gamma35 overexpression Overexpression of DNApol-gamma35 (DNA polymerase gamma) in the nervous system results in a decrease in the median lifespan ranging from 39% to 52% [17999718]. Fly -39 to -52
    Dnmt gene therapy Injecting a virus that contains extra copies of a Dnmt into elderly mice restored their faulty memories to it oiriganal capacity of young ones. Halving the amount of Dnmt produced by younger mice, deteriotes their memory to that of non-treated older mice [http://www.medicaldaily.com/news/20120702/10573/aging-memory-dna-enzyme-forgetfulness-young-old.htm]. Mouse
    Down syndrom Individuals with Down syndrome develop the neuropathological lesions of Alzheimer disease significantly earlier than those without [3158266] and have a shorter lifespan. Down syndrome is cuased by duplication of small regions of chromosome 21 [8197171]. The major features of Down syndrome are mental retardation, characteristic facial features, congenital malformations of the heart and gastrointestinal tract, thyroid disease, and an increased incidence of leukaemia [Epstein, 1989]. Neurons cultured in vivo form individuals with Down syndrome degenerate and exhibit apoptosis [8524410]. Down syndrome neurons also display increased generation of reactive oxygen species and treatment with antioxidants can prevent degeneration. Human
    ectopic Trp53 overexpression Mutant mice with activated Trp53 display enhanced resistance to spontaneous tumours and signs of premature ageing including reduced lifespan, osteoporosis, organ atrophy and a diminished stress tolerance [11780111]. Mouse
    Ef1alpha48D overexpression Overexpression of Ef1alpha48D (transformed with a P-element vector and under control of hsp70 regulatory sequences) results in lifespan extension by 18-41% [2508089]. Fly +18 to +41
    Eip71CD overexpression Overexpression of Eip71CD (alias MsrA) in nervous system extends the lifespan by up to 70%, increases resistance to oxidative stress, and delays the onset of senescence-induced decline in activity levels and reproductive capacity. Eip71CD is a downstream effector of foxo [22310715]. Mean and maximum lifespan is increased by up to 2-% in animals that overexpress Eip71CD [20655917]. Fly +20 to 70 +20
    Elevation of histone expression The elevation of histone expression promotes replicative lifespan extension [20832724]. Yeast
    ERG2 overexpression Overexpression of ERG2 with the promoter of ERG6 (Perg6-ERG2) extends replicative lifespan and this effect was overlapping with moderate DR, because DR can not extend the lifespan of this mutant [Tang et al., unpublished]. Yeast
    faah-1 overexpression faah-1 overexpression reduces eicosapentaenoyl ethanolamide (EPEA), palmitoleyol ethanolamide, linoleyol ethanolamide, as well as arachidonoyl ethanolamide (AEA) levels, delays development, increases thermal stress resistance, and was associated with mean and maximum adult lifespan extension by 19 and 35%, respectively, in presence of abundant food but not under (two different protocols of) DR. Overexpression in pharynx was largely sufficient for this lifespan extension [21562563]. Worm +19 +35
    fabp overexpression Overexpression of fabp (CG6783) throughout the whole body increases mean, median and maximum lifespan by 77, 81 and 13%, increases stress resistant (to paraquat but not starvation), consistently reduces mortality rate across adult ages and reduces the lifespan extension of DR by 12% [22997544]. fabp overexpression increases the dFOXO nuclear localization in the fat-body. mRNA levels of dFOXO target genes l(2)efl and 4E-BP in the adult whole bodies increases in response to overexpression of fabp [22997544]. Females of the genotype Act-GS-Gal4 > UAS-CG6783 exhibit an increase in median lifespan compared to uninduced control in response to feeding with RU486-containing food from day 3 of adulthood (P < 0.0001). Mean lifespan is extended by 10, while maximum lifespan is decreased by 11% [22997544]. Fly +77 +81 +13
    FBP1 overexpression Overexpression of FBP1 shortens chronological lifespan [16199065]. Yeast
    Fgf21 overexpression Overexpression of Fgf-21 increases the mean lifespan by 30% for male mice and 39% for female mice [23066506]. Mice overproducing Fgf21 are lean throughout their lives and remain lean even while eating slightly more than wild-type mice. Fgf21 overproducers tend to be smaller than wild-type mice and female mice were infertile. Although Fgf21 overproducers have significantly lower bone density than wild-type, Fgf21-abundant mice exhibit no ill effects from the reduced bone density and remain active into old age without any broken bones [23066506]. Mouse +30 to +39
    Interventions are an extension of GenAge and GenDR.