• name effect species mean median maximum
    ACB1 deletion ACB1 deletion extends chronological lifespan under starvation/extreme DR. Similar heat-shock resistance and resistance to a very hight concentration of acetic acid (but not resistance to oxidative stress) was enhanced by the deletion of ACB1. Deletion of ACB1 in W303-1A and DBY746 genetic backgrounds on synthetic complete media causes severe growth defects and sightly shorter lifespan and also heat-sensitivity [20657825]. Yeast
    acdh-1 RNAi RNAi knockdown of acdh-1 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan [22810224]. Worm
    acdh-10 RNAi Kncockdown of acdh-10 via RNAi started after the animal reached the late L4 stage increases mean lifespan by 8% significantly and by 3 non-significantly [22103665]. Worm
    acdh-12 RNAi Knockdown of acdh-12 via RNAi started after the animal reached the late L4 stage has no significant effect on mean lifespan [22103665]. Worm
    acdh-12 RNAi RNA interference of acdh-12 starting at hatching or only during the adulthood significantly decreases eat-2 lifespan without affecting the lifespan of wild-type [22810224]. Worm
    acdh-3 RNAi Knockdown of acdh-3 via RNAi started after the animal reached the late L4 stage has no significant effect on mean lifespan [22103665]. Worm
    ACH1 deletion ACH1 deletion cells accumulate a high amount of extracellular acetic acid and display a reduced mean and maximum chronological lifespan. Maximum lifespan is reduced by 32%. Lifespan shortening is completely abrogated by alleviating the acid stress either by a DR regimen that prevents acetic acid production or by transferring chronologically aging mutant cells to water. Deletion of ACH1 is accompanied by reactive oxygen species accumulation, severe mitochondrial damage, and an early insurgence of apoptosis [22754872]. Yeast -32
    acl-11 RNAi RNA interference of acl-11 leads to lifespan extension [12447374]. Worm
    aco-2 RNAi Knockdown of aco-2 via RNAi started after the animal reaches the L4 stage extends mean and maximum lifespan by 9-14% and 9%, respectively [22103665]. Worm +9 to +14 +9
    aco-2 RNAi RNA interference of aco-2 leads to lifespan extension [15998808]. Worm
    ACO1 deletion Deletion of ACO1 decreases mean chronological lifespan by 42 - 56% in diploid cells [21447998]. Yeast -42 to -56
    acs-4 RNAi Knockdown of acs-4 via RNAi started after the animal reached the late L4 stage appeared not significant affect on lifespan (although there was a slight non-significant increase by 5% in mean lifespan). However the same study found also a significant increase in mean lifespan by 6-9% in further experiments [22103665]. Worm +5 to 9%
    acs-5 RNAi RNA interference of acs-5 increases mean lifespan by 52% [17608836]. Worm +52
    act-4 RNAi Knockdown of act-4 started after the animal reached the late L4 stage decreases mean lifespan by 28% [22103665]. Worm
    Activating let-60 mutation The let-60(n1046gf) activating mutation greatly reduces lifespan of wild-type, weakly suppresses constitutive dauer diapause in daf-2 and age-1 mutants and extends lifespan induced by mutation of daf-2 [16164423]. Worm
    Adcy5 knockout Adcy5 knockout mice are to cardiac stress and have an increased median lifespan of 30% as well as an increased maximal lifespan of 12%. Further, they are also protected from age-related reduced bone density and susceptibility to fractures, and reduced cardiac function [17662940]. Mouse +30 +12
    ADE4 deletion ade4 mutation extends chronological lifespan, but not replicative lifespan, and is non-additive with 0.5% glucose or amino-acid DR on chronological lifespan extension. ADE4 deletion in atg16 mutants results only in a partial extension of the chronological lifespan by 0.5% glucose DR [20421943]. Yeast
    AFG3 deletion Deletion of the mitochondrial AAA protease AFG3 increases replicative lifespan by 20% in the alpha and a strains [18340043], but decreases chronological lifespan by 37 - 51% in diploid cells [21447998]. AFG3 deletion changes mean, median and maximum lifespan by 15 to 26% 17 to 30% and -25 to +58%, respectively. AFG3 deletion leads to reduced cytoplasmic mRNA translation and its lifespan extension is independent of Sir2 and Hac1, but requires Gcn4. AFG3 deletion further extends the lifespan of cell deficient in both SIR2 and FOB1, but fails to extend the lifespan of dietary restricted cells or cells lacking GCN4. Gcn4 protein levels are increased in afg3 mutants. The deletion of AFG3 fails to extend the replicative lifespan in the W303AR strain. AFG3 deletion does deletion extend the replicative lifespan at 15°C. Yeast -51 to +20
    age-1 mutation Recessive knockout mutants of age-1 have a 40-65% increase in mean lifespan and a 65-110% increase in maximum lifespan [8608934; 8700226]. age-1(mg44) zygotic null mutants have a mean (99%) and maximum (117%) lifespan extension [18828672]. Even in axenic culture lifespan of age-1 is extended up to 100%. age-1 mutation significantly extends lifespan under AL, but only slightly under sDR [16720740]. age-1 mutants are dauer constitutive [8056303] and display lower brood size as well as increased embryonic lethality [9504918]. Additionally, age-1 mutants have elevated levels of superoxidase dismutase and catalase activities [8389142]. Worm +99 +117
    age-1 RNAi RNAi against age-1 extends lifespan by 30% [8700226; 8608934]. age-1 RNAi increases mean and maximum lifespan by 36-46% and 48-50% [12447374]. RNAi against age-1 increases mean lifespan by 83% [18828672]. age-1(mg44) zygotic null mutants have a mean (99%) and maximum (117%) lifespan extension [18828672]. Worm +36 to +99 +48 to +117
    age-2 mutation Homocygous age-2 mutation increases mean (+43%, +31%, +38%) and maximum (+29%, +36%, +18%)) lifespan by about 20%. age-2 mutant exhibit normal motility, slightly higher swimming rates, reduced fertility and somewhat longer development times and slightly larger size at the first egg laying. Lifespan is extended by reducing the initial mortality rate. age-2 mutation complements other aging gene mutations such as age-1, daf-2, spe-26, clk-1, clk-3 and gro-1. A age-1 age-2 double mutant lives longer than animals with individual mutations and exhibits a longer lifespan at 25 degree Celsius than at 20 degree Celsius [10219000]. Worm +20 +20
    agmo-1 RNAi RNA interference of agmo-1 decreases median lifespan by 30% in wild type animals and 60% in daf-2 mutants [18006689]. Worm -30
    AGP1 deletion Deletion of AGP1 extends chronological lifespan [16418483]. Yeast
    AIM4 deletion AIM4 (alias SOY1) deletion increases chronological and replication lifespan, which is non-additive with DR. On AL mean and maximum replicative lifespan are extended by 63 and 69%, respectively. DR appears to decrease aim4-induced replication lifespan extension, indicating a negative interaction. aim4 mutation does not change DR-induced chronological lifespan extension [21584246]. Yeast +63 +69
    ain-1 RNAi RNA interference of ain-1 decreases median lifespan by 10% in wild type animals, 20% in a daf-2 background and 44% in daf-2/daf-16 double mutants [18006689]. Worm -10
    Interventions are an extension of GenAge and GenDR.