| 14-3-3epsilon mutation | Loss of 14-3-3ε results in increased stress-induced apoptosis, growth repression and extended lifespan of flies, in a foxo-dependent manner. Mean lifespan of males and females is increased by 25% and 49%, respectively. Increased 14-3-3ε expression also reverts foxo-induced growth defects. No effect of lifespan is observed when overexpressing 14-3-3ε in adipose tissue, indicating that endogenous foxo activity in this tissue is low under normal conditions [18665908]. | Fly | +25 to +49 | — | — |
| aak-1 mutation | aak-1 does not appear to be required for the control of lifespan [15574588]. | Worm | — | — | — |
| aak-2 mutation | aak-2(ok524) knockout mutants have a 12% and 18% shorter mean and maximum lifespan, respectively as well as faster age-dependent accumulation of a lipofuscin-like fluorescent pigment in the intestine [15574588]. aak-2 mutation suppresses lifespan extension and delay of the decline in locomotor activity resulting from sDR [17900900]. aak-2 mutation cancels out the lifespan extension effect of sDR and PD, regardless of the concentration of bacteria or peptones. bDR significantly extends lifespan of aak-2 mutants, but to lesser extent than that of wild-type. eat-2 mutation extends the lifespan of aak-2 mutants to the same extent than that of wild-type. Resveratrol does not increase lifespan of aak-2 mutants [19239417]. daf-2(m577);aak-2(ok524) double mutant has a lifespan that is indistinguishable from those of aak-2(ok524) single mutant [15574588]. | Worm | -12 | — | -18 |
| aakb-1 RNAi | RNA interference of aakb-1 results in decreased lifespan and earlier accumulation of lipofuscin [16673436]. | Worm | — | — | — |
| aakb-2 RNAi | RNA interference of aakb-2 results in decreased lifespan and earlier accumulation of lipofuscin [16673436]. | Worm | — | — | — |
| aat-8 RNAi | RNA interference of aat-8 increases mean lifespan by 30% [17608836]. | Worm | +30 | — | — |
| abce-1 RNAi | abce-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| abcx-1 RNAi | RNA interferenceof abcx-1 in adulthood extends mean lifespan by 16% [17521386]. | Worm | +16 | — | — |
| abi-1 RNAi | abi-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| Ablation of median neurosecretary cells | Flies with an ablation of median neurosecretary cells (which eliminates Ilp2 expression) exhibit a significant increase in mean and maximum lifespan over that of control flies and an increase to oxidative stress and starvation. The mutants also exhibit increased storage of lipid and carbohydrate, reduced fecundity, and reduced tolerance of heat and cold [15708981]. The median and maximum lifespan of females is increased by 33.5% and 40%, respectively. In males the median and maximum lifespan is increased by 10.5% and 27%, respectively [15708981]. | Fly | — | +10.5 to +33.5 | +27 to +40 |
| ABP1 deletion | ABP1 deletion increases replicative lifespan by 30% in the alpha strain and decreases replicative lifespan by 20% in the a strain [18340043]. Deletion of ABP1 increases replicative lifespan by 20% in the alpha strain and decreases replicative lifespan by 20% in the a strain [19030232]. | Yeast | -20 to +30 | — | — |
| abs-2 RNAi | RNA interference of abs-2 leads to lifespan extension [16103914]. | Worm | — | — | — |
| Acacb knockout | Acacb-null animals (alias Acc2-/-) exhibit upon regular diet an increase triglyceride breakdown, leaner phenotype, increased insulin sensitivity and no effect on lifespan [17923673]. | Mouse | — | — | — |
| ACB1 deletion | ACB1 deletion extends chronological lifespan under starvation/extreme DR. Similar heat-shock resistance and resistance to a very hight concentration of acetic acid (but not resistance to oxidative stress) was enhanced by the deletion of ACB1. Deletion of ACB1 in W303-1A and DBY746 genetic backgrounds on synthetic complete media causes severe growth defects and sightly shorter lifespan and also heat-sensitivity [20657825]. | Yeast | — | — | — |
| acdh-1 RNAi | RNAi knockdown of acdh-1 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan [22810224]. | Worm | — | — | — |
| acdh-10 RNAi | Kncockdown of acdh-10 via RNAi started after the animal reached the late L4 stage increases mean lifespan by 8% significantly and by 3 non-significantly [22103665]. | Worm | — | — | — |
| acdh-12 RNAi | Knockdown of acdh-12 via RNAi started after the animal reached the late L4 stage has no significant effect on mean lifespan [22103665]. | Worm | — | — | — |
| acdh-12 RNAi | RNA interference of acdh-12 starting at hatching or only during the adulthood significantly decreases eat-2 lifespan without affecting the lifespan of wild-type [22810224]. | Worm | — | — | — |
| acdh-3 RNAi | Knockdown of acdh-3 via RNAi started after the animal reached the late L4 stage has no significant effect on mean lifespan [22103665]. | Worm | — | — | — |
| ACH1 deletion | ACH1 deletion cells accumulate a high amount of extracellular acetic acid and display a reduced mean and maximum chronological lifespan. Maximum lifespan is reduced by 32%. Lifespan shortening is completely abrogated by alleviating the acid stress either by a DR regimen that prevents acetic acid production or by transferring chronologically aging mutant cells to water. Deletion of ACH1 is accompanied by reactive oxygen species accumulation, severe mitochondrial damage, and an early insurgence of apoptosis [22754872]. | Yeast | — | — | -32 |
| acl-11 RNAi | RNA interference of acl-11 leads to lifespan extension [12447374]. | Worm | — | — | — |
| aco-2 RNAi | Knockdown of aco-2 via RNAi started after the animal reaches the L4 stage extends mean and maximum lifespan by 9-14% and 9%, respectively [22103665]. | Worm | +9 to +14 | — | +9 |
| aco-2 RNAi | RNA interference of aco-2 leads to lifespan extension [15998808]. | Worm | — | — | — |
| ACO1 deletion | Deletion of ACO1 decreases mean chronological lifespan by 42 - 56% in diploid cells [21447998]. | Yeast | -42 to -56 | — | — |
| acs-4 RNAi | Knockdown of acs-4 via RNAi started after the animal reached the late L4 stage appeared not significant affect on lifespan (although there was a slight non-significant increase by 5% in mean lifespan). However the same study found also a significant increase in mean lifespan by 6-9% in further experiments [22103665].
| Worm | +5 to 9% | — | — |
GenAge
GenDR
