Denigma

Interventions

  • Species: + -
    Budding yeast « 
  • Manipulation: + -
    Transposition «  Loss‑of‑Function (2)   Knockdown (1)   Mutation (3)  
    • name effect species mean median maximum
    SCH9 Transposition Transposon-mediated mutagenesis of SCH9, which encodes for a serine threonine kinase homologous to Akt/PKB, increases resistance to oxidants and thermal stress as well as extends chronological lifespan by 30% [11292860]. Yeast +30 — —
    CYR1 transposition Transposon-mutagenized CYR1 increases resistance to oxidants and extends chronological lifespan by up to 90%. Stress-resistance transcription factors Msn2/Msn4 and protein kinase Rim15 are required for this lifespan extension [11292860]. Yeast +300 — —
    IPT1 transposition Transposon-mediated mutation of IPT1 increases oxidative stress resistance and chronological lifespan by 40% [16527275]. Yeast +40 — —
    • 3 interventions
    Interventions are an extension of GenAge and GenDR.