| abce-1 RNAi | abce-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| abi-1 RNAi | abi-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| alg-1 RNAi | Adult-specific knockdown of the C. elegans argonaute-like gene 1 *alg-1* results in shortened lifespan with a reduction in the mean and maximum lifespan by 9 - 16% and 14%, respectively [21810936]. | Worm | -9.6 to -16.1 | — | -13.7 |
| aph-2 RNAi | aph-2 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| apr-1 RNAi | apr-1 RNAi in the adulthood extends the lifespan [99999999]. | Worm | — | — | — |
| aps-1 RNAi | aps-1 RNAi in the adulthood extends mean lifespan by 8% without any apparent effect on maximum lifespan [23144747]. | Worm | +7.9 | — | 0 |
| asb-1 RNAi | asb-1 RNAi in the adulthood extends the mean lifespan by 7% without changing the maximum lifespan [23144747]. | Worm | +6.4 | — | 0 |
| B0280.9 RNAi | B0280.9 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| B0393.6 RNAi | B0393.6 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| bec-1 RNAi | bec-1 is required for normal dauer morphogenesis and lifespan extension. Knockdown of bec-1 via RNA interference results in a shortened mean and maximum lifespan by 14 and 5% [12958363]. bec-1 RNAi does not significantly change the lifespan of wild-type, but completely suppresses the longevity phenotype of eat-2 mutation [17912023; 18282106] and prevents lifespan extension by daf-2(e1370) mutation [12958363]. bec-1 RNAi causes the formation of abnormal dauers in a daf-2(e1379) background [12958363]. | Worm | -14 | — | -5 |
| beta-transducin RNAi | beta-transducin RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| rict-1 RNAi | C. elegans with mutations in the TORC2 complex gene rict-1 (Rictor) grow slowly and have small body size, and live slightly longer than wild-type when maintained on ârichâ food such as the RNAi feeding strain HT115 and at elevuated temperature (25 degree Celsius) [Soukas et al., 2009 in (Robida-Stubbs et al., 2012)]. rict-1 RNAi at 20 degree Celsius in the adulthood increases mean, median, 75th %ile and maximum lifespan by 12-42, 22-29, 13-32 and 28-54%, respectively, dependent on skn-1. daf-16 is not required for lifespan to be increased by rict-1 RNAi, or when TORC1 and TORC2 are blocked by ragc-1;rict-1 RNAi. rict-1 RNAi extends mean, median, 75th %ile and maximum lifespan in the intestine-specific RNA stains VPS288 by 12-18, 19, 13-18 and 16%, respectively [22560223]. | Worm | +12 to +42 | +22 to +42 | +28 to +54 |
| C14A4.11 RNAi | C14A4.11 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| C14A4.14 RNAi | C14A4.14 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| C16C10.2 RNAi | C16C10.2 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| C47D12.2 RNAi | C47D12.2 RNAi in the adulthood extends mean and maximum lifespan by 6 and 9% [23144747]. | Worm | +5.5 | — | +8.7 |
| C47D12.8 RNAi | C47D12.8 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| C56C10.10 RNAi | C56C10.10 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| cchl-1 RNAi | cchl-1 RNAi extends mean and maximum lifespan by 55% and 57%, respectively. Lifespan extension by RNAi of cchl-1 is not suppressed by daf-16 [12447374].
cchl-1 RNAi animals have lower ATP content and oxygen consumption [12447374]. | Worm | +55 | — | +57 |
| cdc-25.3 knockout | cdc-25.3 knockout mutants also display increased thermotolerance and a 40% lifespan extension [16741121]. | Worm | +40 | — | — |
| cdk-1 RNAi | cdk-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| ceh-6 RNAi | ceh-6 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| chn-1 RNAi | chn-1 RNAi in the adulthood extends mean and maximum lifespan by 7 and 9%, respectively [23144747]. | Worm | +7.1 | — | +8.7 |
| ckr-1 RNAi | ckr-1 RNAi significantly reduces lifespan of eat-2 but not that of age-1 nor clk-1 mutants [19783783]. | Worm | — | — | — |
| ckr-2 RNAi | ckr-2 RNAi significantly reduces the lifespan of eat-2 but not that of age-1 nor clk-1 mutants [19783783]. | Worm | — | — | — |
GenAge
GenDR
