| YME1 deletion | Deletion of YME1 decreases chronological lifespan by 50% [17492370] as well as replicative lifespan by 45% in the alpha strain [18340043]. | Yeast | -45 to -50 | — | — |
| YLR460C deletion | Deletion of YLR460C decreases replicative lifespan by 30% in the alpha strain [19030232]. | Worm | -30 | — | — |
| YLR422W deletion | Deletion of YLR422W increases replicative lifespan by 25% in the alpha strain [19030232]. | Yeast | +25 | — | — |
| YKU80 deletion | Deletion of YKU80 shortens replicative lifespan, but does not accelerate the normal aging process [10521401]. YKU80 null mutant is defective for non-homologous end-joining [8754818] and for telomere silincing [9501103; 9635192] | Yeast | — | — | — |
| YKU70 deletion | Deletion fo YKU70 shortens lifespan, but does not accelerate the normal aging process [10521401]. YKU70 null mutants are defective for non-homologous end-joining [8754818] and for telomeric silencing [9635192]. | Yeast | — | — | — |
| YKL069W deletion | Deletion of YKL069W increases sensitivity to oxidative stress and decreases replicative lifespan [19049972]. | Yeast | — | — | — |
| YIA6 deletion | Deletion of YIA6 decreases replicative lifespan by 30% in the a strain [18340043]. | Yeast | -30 | — | — |
| YHF1 deletion | Deletion of YFH1 decreases replicative lifespan by 50% [15130665]. | Yeast | -50 | — | — |
| YHC3 deletion | YHC3 deletion decreases 10-20% shortened lifespan [16435200]. | Yeast | -10 to -20 | — | — |
| YHB1 deletion | Deleting YHB1 partially abolished DR-induced replicative lifespan extension, whereas deleting SFA1 alone had no effect. sfa1;yhb1 double mutant cancels out the ability of moderate DR to extend replicative lifespan, but not chronological lifespan. Yhb1 and Sfa1 may play redundant roles [21584246]. | Yeast | — | — | — |
| YGR071C deletion | Deletion of YGR071C decreases replicative lifespan by 60% in the alpha strain [19030232]. | Yeast | -60 | — | — |
| YGL235W deletion | YGL235W increases replicative lifespan by 20% in the alpha strain [19030232]. | Yeast | +20 | — | — |
| YER187W deletion | Deletion of YER187W increases replicative lifespan by 30% in the alpha strain [19030232]. | Yeast | +30 | — | — |
| YER186C deletion | Deletion of YER186C increases replicative lifespan by 30% in the alpha strain [19030232]. | Yeast | +30 | — | — |
| YDR307W deletion | Deletion of YDR307W increases replicative lifespan by 30% in the alpha strain [19030232]. | Yeast | +30 | — | — |
| YDR262W deletion | Deletion of YDR262W decreases replicative lifespan by 30% in the alpha strain [19030232]. | Yeast | -30 | — | — |
| YDR248C deletion | Deletion of YDR248C increases replicative lifespan by 20% in the alpha strain [19030232]. | Yeast | +20 | — | — |
| YDR132C deletion | Deletion of YDR132C decreases replicative lifespan by 35% in the alpha strain [19030232]. | Yeast | -35 | — | — |
| YDR124W deletion | Deletion of YDR124W increases replicative lifespan by 30% in the alpha and decreases lifespan by 10% in a strain [19030232]. | Yeast | -10 to +30 | — | — |
| YDL180W deletion | YDL180W deletion impairs DR-mediated replicative lifespan extension, but does not change lifespan on AL significantly [22912585]. | Yeast | +5 | — | -6 |
| YDC1 overexpression | YDC1 overexpression decreases chronological lifespan by 40% [19059240]. | Yeast | -40 | — | — |
| YBR238C deletion | Deletion of YBR238C increases mean replicative lifespan by 25 to 34% in the alpha and a strains [16293764; 19030232]. | Yeast | +25 to +34 | — | — |
| YBR225W deletion | Deletion of YBR225W decreases replicative lifespan by 40% in the alpha strain [19030232]. | Yeast | -40 | — | — |
| yata mutation | yata mutation shortens the maximum lifespan by 68% and results in progressive deterioration of the nervous tissues and aberrant accumulation of Sec23 [19209226]. | Fly | — | — | -68 |
| Y47D3A.29 RNAi | RNAi against Y47D3A.29 decreases mean and maximum lifespan by 19-26% and 34% [18059442]. | Worm | -19-26 | — | -34 |
GenAge
GenDR
