| pex1 mutation | Mutation of the promoter region of pex1(S4868), results in lower expression levels and increases lifespan in males and females by 16% and 13%, respectively. pex1 mutation increases mean and maximum lifespan and males/females by 27-23/14-19% and 0-15%, respectively [22509016]. | Fly | +14 to +27 | — | 0 to +15 |
| Hsp70Ba overexpression | Hsp70Ba overexpression reduces mean and maximum lifespan up to 30% [19420297]. | Fly | -30 | — | -30 |
| HES1 overexpression | Elevation of HES1 levels by an ERG6 promoter reduces mean, median and maximum replicative lifespan by 25, 18 and 29% [Geber et al., unpublished] | Yeast | -25 | -18 | -29 |
| FRE6 deletion | FRE6 deletion increases mean replicative lifespan by 14% and cancels out the lifespan extending effect of DR [22912585]. | Yeast | +14 | — | -2 |
| mir-239 overexpression | Overexpressing mir-239 decreases mean and maximum lifespan by 13 and 17 - 33%, respectively [21129974]. | Worm | -13 | — | -17 to -33 |
| old-1 overexpression | Overexpression of old-1 in transgenic animals increases mean and maximum lifespan by 40-100% (average 65%) and 97%, respectively. old-1 overexpression of increases stress resistance (to heat by 20% and ultraviolet irradiation by 33%) without altering development or fertility. Effects of old-1 on lifespan and stress resistance is under regulation of daf-16 [9768365]. | Worm | +40 to +100 | — | +97 |
| CG10383 overexpression | Overexpression of CG10383 in males increases mean and maximum lifespan by 12% and 8%, respectively [22366109]. | Fly | +12 | — | +8 |
| CG13890 overexpression | Overexpression of CG13890 (DCI) throughout the whole body increases mean and median lifespan by 35 and 31%, but decreases maximum lifespan by 6%, increases stress resistant (to paraquat and starvation), consistently reduces the mortality rate across adult ages and reduces the lifespan extension of DR by 15% [22997544].
CG6783 overexpression increases the dFOXO nuclear localization in the fat-body. mRNA levels of dFOXO target genes l(2)efl and 4E-BP in the adult whole bodies increases in response to overexpression of CG6783 [22997544]. | Fly | +35 | +31 | +6 |
| LAG2 overexpression | When LAG2 is overexpressed in SP1 strain, the mean and maximum replicative lifespan is extended by about 36% and 54%, respectively. Overexpression induced at generation 12 similarly increases replicative lifespan [8760941]. | Yeast | +36 | — | +54 |
| VMA1 overexpression | Overexpression of VMA1 increases vacuolar acidity and suppresses age-induced mitochondrial dysfunction of aged cells (17 or 18 cell divisions) which requires the V-ATPase activity. VMA1 overexpression significantly increases mean, median and maximum lifespan by 39 - 45%, 39 - 48% and 50 - 60%, respectively. DR (0.5% glucose restriction) does not further increase the lifespan of VMA1 overexpression strain [23172144]. | Yeast | +39.3 to +44.8 | +39.3 to +48.3 | +50.0 to +60.0 |
| phi-44 RNAi | phi-44 RNAi leads to 46% mean and 50% maximum lifespan extension. Lifespan extension by phi-44 is not suppressed by daf-16.
phi-44 RNAi animals have lower ATP content and oxygene consumption [12447374]. | Worm | +46 | — | +50 |
| Gclc overexpression | Overexpression of Gclc extended mean and maximum lifespan by up to 50% [16148000]. | Fly | +50 | — | +50 |
| age-1 RNAi | RNAi against age-1 extends lifespan by 30% [8700226; 8608934]. age-1 RNAi increases mean and maximum lifespan by 36-46% and 48-50% [12447374]. RNAi against age-1 increases mean lifespan by 83% [18828672]. age-1(mg44) zygotic null mutants have a mean (99%) and maximum (117%) lifespan extension [18828672]. | Worm | +36 to +99 | — | +48 to +117 |
| hsp-6 overexpression | Overexpression of hsp-6 from a muscle-specific promoter extends lifespan mean and maximum lifespan by 43 and 45% relatively to animals expressing GFP from the same promoter [11959102]. | Worm | +43 | — | +45 |
| rps-27 RNAi | Knockdown of rps-27 by RNAi extends mean and maximum lifespan by 50 and 44%, respectively [19293945]. | Worm | +50 | — | +44 |
| old-2 overexpression | Overexpression of old-2 increases slightly, although statistically significant mean and maximum lifespan by 19 and 44% [9768365]. | Worm | +19 | — | +44 |
| lyz overexpression | Overexpression of lyz increases mean, median, and maximum lifespan by 26, 30 and 44% [22737090]. | Worm | +26 | +30 | +44 |
| sod1 overexpression | Overexpression of sod1 increases mean, median, and maximum lifespan by 21, 25, and 29% [22737090]. | Worm | +23 | +25 | +44 |
| lmp-2 overexpression | Overexpression of lmp-2 increases mean, median and, maximum lifespan by 32, 35, and 41% [22737090]. | Worm | +32 | +35 | +41 |
| SIR3 activating mutation | The S755A allele of SIR3 (which prevents phosphorylation of Sir3) results in a 40% increase in mean and maximum lifespan [12640455]. | Yeast | +40 | — | +40 |
| MTF-1 overexpression | MTF-1 overexpression in either the peripheral nervous system or motorneurons extends both mean and maximum lifespan by 40% in males [18775584]. | Fly | +40 | — | +40 |
| mir-246 overexpression | mir-246 overexpression increases mean and maximum lifespan by 6 and 5 - 14%, respectively [21129974]. | Worm | +6.3 | — | +4.8 to +14.3 |
| NF1 overexpression | Overexpression of NF1 increases mitochondrial respiration and reduced ROS production. It increases mean lifespan by 49% in males and 68% in females and maximum lifespan by 38% in males and 52% in females. It also improved reproductive fitness [17369827]. | Fly | +49 to +68 | — | +38 to +52 |
| Spargel overexpression | Tissue-specific overexpression of dPGC-1 in stem and progenitor cells within the digestive tract of females flies extends the median and maximum lifespan of females by up to 33% and 37%. Those mutants display a delay in the onset of aging-related changes in the intestine, leading to improved tissue homoeostasis in old flies [22055505]. | Fly | — | +33 | +37 |
| sod-1 overexpression | sod-1 overexpression increases mean, median, and maximum lifespan by 32, 25, and 35% [22737090]. | Worm | +32 | +25 | +35 |
GenAge
GenDR
