| glc-4 mutation | Mutation of glc-4 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. glc-4(JD31) increases the mean, 75%ile, and maximum lifespan by 13-23, 11-23, 19-34%. Lifespan extension by glc-4 mutation is totally abolished by RNAi inactivation of either daf-16 or skn-1. eat-2 RNAi further enhances the extension of lifespan by glc-4 mutation [22768380].
Mutation of glc-4 suppresses pheromone-induced dauer formation [22768380]. | Worm | +13 to +23 | — | +18 to +34 |
| F57A8.4 mutation | Mutation of F57A8.4 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. F57A8.4(tm4341) mutation extends the mean, 75%ile, and maximum lifespan by 18-38, 21-25, and 42-68%. Lifespan extension by gar-3 mutation is not abolished by RNAi inactivation of either daf-16 nor skn-1. eat-2 RNAi shortens the lifespan of F57A8.4 mutants [22768380].
Mutation of F57A8.4 suppresses pheromone-induced dauer formation [22768380].
| Worm | +18 to +38 | — | +42 to +68 |
| cha-1 mutation | Mutation of cha-1 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. cha-1(TY1652) mutation extends mean, 75%ile, and maximum lifespan by 23, 29, and 38%. The cha-1(PR1152) allele extends mean, 75%ile, and maximum lifespan by 22-49, 18-25, and 11-21%. Lifespan extension by cha-1 mutation is not abolished by daf-16 RNAi inactivation. eat-2 RNAi shortens the lifespan of cha-1 mutants [22768380]. | Worm | +22 to +49 | — | +11 to +21 |
| unc-17 mutation | Mutation of unc-17 extends lifespan on NGM agar covered with killed or live bacteria. unc-17(CB933) extends mean, 75%ile, and maximum lifespan by 31-79%, 68-89%, and 68-79%. Lifespan extension by unc-17 mutation is totally abolished by RNAi inactivation of daf-16, but not skn-1. eat-2 RNAi further enhances the extension of lifespan by mutations of unc-17 [22768380].
Mutation and RNAi of unc-17 suppresses pheromone-induced dauer formation [22768380]. | Worm | +31 to +79 | — | +68 to +79 |
| gar-3 mutation | Mutation of gar-3 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. gar-3(VC670) mutation extends mean, 75%ile, and maximum lifespan by 5-18, 4-7 and 15-56%. Lifespan extension by gar-3 mutation is not abolished by RNAi inactivation of daf-16, skn-1, or eat-2 [22768380]. | Worm | +5 to +18 | — | +15 to +56 |
| tdp-1 mutation | tdp-1(ok803) mutation increases mean and maximum lifespan at 20 degree Celsius but not at 25 degree Celsius. tdp-1(ok803) reduce the lifespan of daf-2(e1370) mutants, but does not does not reduces the lifespan of daf-16(mu86) mutants [Vaccaro et al. 2012]. | Worm | — | — | — |
| aak-2 constitutive active mutation | A constitutive active mutation of aak-2 is sufficient to cause increase stress resistance as well as to significantly extend lifespan. Both increased stress resistance and extended lifespan is reverted in daf-16 knockdown by RNAi [17900900]. | Worm | — | — | — |
| pha-4 mutation | Mutants of pha-4 do not respond to bacterial DR. Therefore, loss of pha-4 completely blocks the response to varying food concentration. Reduction of pha-4 does not suppress the long lifespan of daf-2 mutants or animals with defective electron transport chain [17476212]. IF significantly extends lifespan of pha-4 [19079239]. sDR extends lifespan of mutants with a temperature sensitive allele of pha-4, but not daf-16 RNAi [19239417].
| Worm | — | — | — |
| Overexpression of constitutive nuclear DAF-16 | Overexpression of constitutive nuclear forms of DAF-16 increases lifespan only slightly [11381260]. | Worm | — | — | — |
| smk-1 mutation | Loss of smk-1 by temperature sensitive allele suppresses the extended lifespan under optimal bDR, but not the response to DR itself [17476212]. | Worm | — | — | — |
| wwp-1 mutation | Loss of wwp-1 function by mutation reduces lifespan at 25 degree Celsius, but not 20 degree Celsius. Lifespan of wwp-1 mutants across entire food concentration range by bacterial dilution in liquid culture or on solid plates does not noticeable change. Reduced levels of wwp-1 completely suppress the extended longevity of eat-2 mutants [19553937].
| Worm | — | -9 | — |
| ubc-18 mutation | Loss of ubc-18 function by mutation reduces lifespan at 25 degree Celsius, but only slightly at 20 degree Celsius [19553937]. | Worm | — | — | — |
| egl-9 mutation | egl-9 deletion does not affect lifespan under AL. Lifespan extension under modified sDR regimen is diminished by egl-9 mutation. egl-9 mutation significantly suppresses the lifespan extension by a strong loss-of-function allele of eat-2. Lifespan extension by deletion mutants of rsks-1 is fully suppressed by egl-9 mutation [19461873]. | Worm | — | — | — |
| ire-1 mutation | ire-1 mutation reduces slightly the lifespan under AL, but reduces significantly the lifespan extension by DR. ire-1 mutant has a significantly reduced slope in mean lifespan versus food concentrations relative to wild-type. ire-1 mutation fully suppresses lifespan extension by hif-1 mutation under AL and DR conditions [19461873]. | Worm | — | — | — |
| hif-1 mutation | hif-1 mutation does not suppress lifespan extension of bDR or eat-2 mutation [19372390]. hif-1 deletion extends lifespan by 24%. hif-1 mutation extends lifespan under AL, but does not further extend lifespan extension under modified sDR. hif-1 mutation does not further extend rsks-1 lifespan. pha-4 RNAi slightly reduces lifespan in wild-type and hif-1 mutants, but hif-1 mutation extends lifespan of animals treated with control or pha-4 RNAi to a similar level [19461873].
| Worm | — | — | — |
| hsp-12.6 mutation | hsp-12.6 loss-of-function mutation significantly extends lifespan under AL and significantly suppresses intermittent fasting (IF)-induced increase in lifespan, to a similar extend to that of daf-16 mutation. The extent of IF-induced longevity in daf-16 hsp-12.6 double mutant is similar to that of single hsp-12.6 or daf-16 mutants. hsp-12.6 and daf-16 function in same signaling pathway [19079239]. | Worm | — | — | — |
| aak-1 mutation | aak-1 does not appear to be required for the control of lifespan [15574588]. | Worm | — | — | — |
| YLR460C deletion | Deletion of YLR460C decreases replicative lifespan by 30% in the alpha strain [19030232]. | Worm | -30 | — | — |
| him-6 RNAi | him-6 mutants have a low brood size, a shortened lifespan, and an increased amount of germ-line apoptosis [16181657]. | Worm | — | — | — |
| D1054.8 RNAi | RNA interference of D1054.8 results in lifespan extension [15998808]. | Worm | — | — | — |
| URE2 deletion | Deletion of URE2 increase mean replicative lifespan by 21-31% in BY4742 [16293764]. URE2 deletion increases replicative lifespan increased by 20% in the alpha strain [19030232]. | Worm | +20 to +31 | — | — |
| unc-80 mutation | The unc-80(e1069) allele has no significant effect on lifespan [9789046].
unc-80 mutant displays irregular movement [4366476] | Worm | — | — | — |
| unc-79 mutation | The unc-79(e1068) allele has no significant effect on lifespan [9789046].
unc-78 mutants display irregular movement [4366476]. | Worm | — | — | — |
| unc-78 mutation | Mutation in unc-78 has no effect on lifespan [9789046].
unc-78 mutants move slowly [7190524]. | Worm | — | — | — |
| unc-76 mutation | unc-76(e911) allele extends male lifespan by about 50%, but has no effect on hermaphrodite lifespan [10747056].
unc-76 mutants are uncoordinated [4366476]. | Worm | +50 | — | — |
GenAge
GenDR
