sir-2.4 RNAi | RNA interference against sir-2.4 does not change the mean or maximum lifespan of wild-type not the increased lifespan of daf-2(e1370) mutants [Tishkoff et al. 2012]. | Worm | — | — | — |
let-23 RNAi | Postdevelopmental inactivation of let-23 by RNA interference extends the lifespan by 5.6% [New Longevity Regulators]. | Worm | +5.6 | — | — |
cku-70 RNAi | RNA interference of cku-70 further increases the lifespan of daf-2 mutants. Lifespan of daf-16 mutants is slightly decreased by cku-70 RNAi [16099946]. | Worm | — | — | — |
C33H5.18 RNAi | RNA interference of C33H5.18 decreases median lifespan by 44% in wild type animals, 77% in a daf-2 background and 14% in daf-2/daf-16 double mutants [18006689]. | — | — | -44 | — |
cyp-42A1 RNAi | RNA interference of cyp-42A1 decreases median lifespan by 39% in wild type animals, 77% in a daf-2 background and 37% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -39 | — |
cyp-33E2 RNAi | RNA interference of cyp-33E2 increases mean lifespan by 18% [17608836]. | Worm | — | — | — |
cwp-4 RNAi | RNA interference of cwp-4 extends lifespan [15998808]. | Worm | — | — | — |
cul-1 RNAi | RNAi of cul-1 decreases lifespan of daf-2 mutant, but not of wild-type or glp-1 mutant. The CUL-1 complex functions in postmitotic, adult somatic tissues of insulin/insulin-like growth factor-1-signaling mutants to enhance longevity. It may act, at least in part, by promoting the transcriptional activity of DAF-16/FOXO [17392428]. | Worm | — | — | — |
cua-1 RNAi | RNA interference of cua-1 decreases median lifespan by 12% in wild type animals and 30% in daf-2 mutants. | Worm | — | -12 | — |
cst-1 RNAi | Knockdown of cst-1 shortens lifespan and accelerates tissue aging [16751106]. | Worm | — | — | — |
crn-5 RNAi | RNA interference against crn-5 in adulthood results in a 41% increase in mean lifespan [17411345]. | Worm | +41 | — | — |
col-93 RNAi | RNA interference of col-93 results in extended lifespan [15998808]. | Worm | — | — | — |
cnb-1 mutation | RNA interference of cnb-1 increases mean lifespan by 30% [17673661]. | Worm | +30 | — | — |
cit-1.2 RNAi | RNA interference cit-1.2 decreases median lifespan by 27% in daf-2 mutants [18006689]. | Worm | — | -27 | — |
chk-1 RNAi | RNA interference of chk-1 increases lifespan by 15 to 25% [16741121]. | Worm | +15 to +25 | — | — |
cep-1 RNAi | RNA interference of cep-1 increases mean lifespan up to 18% which is dependent upon functional daf-16 [17895432]. | Worm | +18 | — | — |
cel-1 RNAi | RNA interference of cel-1 decreases median lifespan 76% in daf-2 mutants, 15% in daf-2/daf-16 double mutants, and 59% wild-type animals [18006689]. | Worm | — | -76 | — |
ceh-18 RNAi | RNA interference of ceh-18 extends lifespan [15998808]. | Worm | — | — | — |
cdk-7 RNAi | RNA interference of cdk-7 decreases median lifespan by 18% in a daf-2 background and 19% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -18 | — |
cdc-25.3 knockout | cdc-25.3 knockout mutants also display increased thermotolerance and a 40% lifespan extension [16741121]. | Worm | +40 | — | — |
cdc-25.1 RNAi | RNA interference of cdc-25.1 results in increased thermotolerance and extended lifespan [16741121]. cdc-25.1 RNAi extends mean and maximum lifespan by 10 and 13%, respectively [21129974].
Lifespan extension by cdc-25.1 RNAi is cancelled out by mir-71 mutation [21129974]. | Worm | +10.0 | — | +12.5 |
cct-6 RNAi | RNA interference cct-6 in adulthood results in a 20% increase in mean lifespan [17411345]. | Worm | +20 | — | — |
cct-4 RNAi | RNA interference of cct-4 in adulthood results in a 28% increase in mean lifespan [17411345]. | Worm | +28 | — | — |
ccr-4 RNAi | RNA interference of ccr-4 decreases median lifespan by 33% in wild type animals, 37% in a daf-2 background and 44% in daf-2/daf-16 double mutants [18006689]. | Worm | -33 | — | — |
cco-2 RNAi | RNA interference of cco-2 results in a 53-57% increase in mean lifespan [16103914]. | Worm | +45 to +57 | — | — |