Interventions

  • name effect species mean median maximum
    sir-2.4 RNAi RNA interference against sir-2.4 does not change the mean or maximum lifespan of wild-type not the increased lifespan of daf-2(e1370) mutants [Tishkoff et al. 2012]. Worm
    let-23 RNAi Postdevelopmental inactivation of let-23 by RNA interference extends the lifespan by 5.6% [New Longevity Regulators]. Worm +5.6
    cku-70 RNAi RNA interference of cku-70 further increases the lifespan of daf-2 mutants. Lifespan of daf-16 mutants is slightly decreased by cku-70 RNAi [16099946]. Worm
    C33H5.18 RNAi RNA interference of C33H5.18 decreases median lifespan by 44% in wild type animals, 77% in a daf-2 background and 14% in daf-2/daf-16 double mutants [18006689]. -44
    cyp-42A1 RNAi RNA interference of cyp-42A1 decreases median lifespan by 39% in wild type animals, 77% in a daf-2 background and 37% in daf-2/daf-16 double mutants [18006689]. Worm -39
    cyp-33E2 RNAi RNA interference of cyp-33E2 increases mean lifespan by 18% [17608836]. Worm
    cwp-4 RNAi RNA interference of cwp-4 extends lifespan [15998808]. Worm
    cul-1 RNAi RNAi of cul-1 decreases lifespan of daf-2 mutant, but not of wild-type or glp-1 mutant. The CUL-1 complex functions in postmitotic, adult somatic tissues of insulin/insulin-like growth factor-1-signaling mutants to enhance longevity. It may act, at least in part, by promoting the transcriptional activity of DAF-16/FOXO [17392428]. Worm
    cua-1 RNAi RNA interference of cua-1 decreases median lifespan by 12% in wild type animals and 30% in daf-2 mutants. Worm -12
    cst-1 RNAi Knockdown of cst-1 shortens lifespan and accelerates tissue aging [16751106]. Worm
    crn-5 RNAi RNA interference against crn-5 in adulthood results in a 41% increase in mean lifespan [17411345]. Worm +41
    col-93 RNAi RNA interference of col-93 results in extended lifespan [15998808]. Worm
    cnb-1 mutation RNA interference of cnb-1 increases mean lifespan by 30% [17673661]. Worm +30
    cit-1.2 RNAi RNA interference cit-1.2 decreases median lifespan by 27% in daf-2 mutants [18006689]. Worm -27
    chk-1 RNAi RNA interference of chk-1 increases lifespan by 15 to 25% [16741121]. Worm +15 to +25
    cep-1 RNAi RNA interference of cep-1 increases mean lifespan up to 18% which is dependent upon functional daf-16 [17895432]. Worm +18
    cel-1 RNAi RNA interference of cel-1 decreases median lifespan 76% in daf-2 mutants, 15% in daf-2/daf-16 double mutants, and 59% wild-type animals [18006689]. Worm -76
    ceh-18 RNAi RNA interference of ceh-18 extends lifespan [15998808]. Worm
    cdk-7 RNAi RNA interference of cdk-7 decreases median lifespan by 18% in a daf-2 background and 19% in daf-2/daf-16 double mutants [18006689]. Worm -18
    cdc-25.3 knockout cdc-25.3 knockout mutants also display increased thermotolerance and a 40% lifespan extension [16741121]. Worm +40
    cdc-25.1 RNAi RNA interference of cdc-25.1 results in increased thermotolerance and extended lifespan [16741121]. cdc-25.1 RNAi extends mean and maximum lifespan by 10 and 13%, respectively [21129974]. Lifespan extension by cdc-25.1 RNAi is cancelled out by mir-71 mutation [21129974]. Worm +10.0 +12.5
    cct-6 RNAi RNA interference cct-6 in adulthood results in a 20% increase in mean lifespan [17411345]. Worm +20
    cct-4 RNAi RNA interference of cct-4 in adulthood results in a 28% increase in mean lifespan [17411345]. Worm +28
    ccr-4 RNAi RNA interference of ccr-4 decreases median lifespan by 33% in wild type animals, 37% in a daf-2 background and 44% in daf-2/daf-16 double mutants [18006689]. Worm -33
    cco-2 RNAi RNA interference of cco-2 results in a 53-57% increase in mean lifespan [16103914]. Worm +45 to +57
    Interventions are an extension of GenAge and GenDR.