• name effect species mean median maximum
    nhr-62 Mutation Mutation in *nhr-62* suppresses the lifespan extension of eat-2(ad465) animals (p<0.001) [Heestand et al. 2013]. Worm
    mrpl-37 RNAi Knockdown of mrpl-37 increases lifespan by 41% [23698443]. Worm +41
    mrpl-2 RNAi Knockdown of mrpl-2 increases lifespan by 54% [23698443]. Worm +54
    mrpl-1 RNAi Knockdown of mrpl-1 increases lifespan by 57% [23698443]. Worm +57
    ttl-9 RNAi Knockdown of ttl-9 throughout the entire life increases the lifespan by 3% [23698443]. Worm +3
    nkcc-1 RNAi Knockdown of nkcc-1 throughout the entire life increases the lifespan by 23% [23698443]. Worm +23
    mrps-5 RNAi Knockdown of mrps-5 throughout the entire life increases the lifespan by 60%. mrps-5 RNAi prevents aging-associated functional decline and alters mitochondrial function. Knocking down mrps-5 after early development no longer affects nematode lifespan. When RNAi of mrps-5 was performed during the larval stages only, lifespan increases by 48%, whereas RNAi started from the L4 stage has no effect. mrps-5 RNAi results in fragmented mitochondria. mrps-5 RNAi increases lifespan by 40% in widltype, 37% in daf-16(mu86), 40% in sir-2.1(ok434) 69% in aak-2(ok524) and 112% in mev-1(kn1). Knockdown of cco-1 does not extend the lifespan of mrps-5 RNAi [23698443]. Worm +60
    miR-277 inhibition Transgenic inhibition of miR-277 with a miRNA sponge construct shortens lifespan [23669073]. Fly
    yata mutation yata mutation shortens the maximum lifespan by 68% and results in progressive deterioration of the nervous tissues and aberrant accumulation of Sec23 [19209226]. Fly -68
    snz mutation Mutation in snz increases maximum lifespan of both sexes by up to 66%, while the median female lifespan is approximately 85% higher and that of males around 72% [18478054]. Fly +72 to +85 +66
    SNF4Agamma deletion Deletion of SNF4Agamma from the first day of the imaginal stage shortens mean lifespan by 23% and causes morphological and behavioural features of premature aging [18219227]. Fly -23
    Rbp9 mutation Rbp9 mutation significantly decreases longevity with a 33% reduction in median lifespan of males [20589912]. Fly -33
    Prx5 mutation dprx5(-/-) null mutants are comparatively more susceptible to oxidative stress, have higher incidence of apoptosis, and a shortened mean lifespan, but thee is no significant difference in maximum lifespan (10% survival) [21826223]. Fly
    pex16 mutation pex16 mutation lead to a reduced mean lifespan of one-third in females and on-fourth in males. The short lifespan can be rescued by the simultaneous overexpression of pex16 in the fat body and differentiated neurons [21826223]. Mutant flies lack normal peroxisomes, have an reduced adult body size (70%-85% smaller than controls) and rozy eyes, show locomotion defects in the development of the nervous system [21826223]. Fly -33 to -75
    Nlaz mutation Absence of Nlaz, which is homologous to ApoD, results in a reduced lifespan in both sexes. Median lifespan is 30.8% and 22.5% lower in females and males, respectively. Maximum lifespan is reduced by 12% and 30% in females and males [21376794]. Fly -22.5 to -30.8 -12 to -30
    Mlp84B RNAi RNA interference of Mlp84B specifically in the heart results in bradycardia and heart rythm abnormalities as well as a shorter mean lifespan in males but not in females [18083727]. Fly
    Loco mutation Reduced expression of Loco due to hetero-deficient results in a 17-20% longer mean lifespan for both male and females, besides the fact that the homozygous deficiency of loco is lethal. Several of these long-lived mutants are more resistant to stresses such as starvation, oxidation ad heat. Additional mutant have higher Manganese-containing superoxide dismutase (MnSOD) activity, increased fat content an diminished cAMP levels. Loco RGS domain is required for the regulation of longevity as deletion analysis suggest [21776417]. Fly +17 to +20
    Lnk mutation Loss of Lnk function results in increased median (14% in females and 17.5 in males) and maximum lifespan, reduced female fecundity and improves survival under conditions of oxidative stress and starvation. Heterozygousity does not result in any significant differences in lifespan in either males or females. Moreover, lifespan extension in one of the female homozygous mutant is fully rescued by the introduction of a Lnk genomic rescue construct [20333234]. Fly -14 to -17.5
    kermit disruption The disruption of kermit (alias dGIPC) function results in premature loss of locomotor activity and reduced mean lifespan [21029723].
    CG3776 underexpression Underexpression of CG3776 (alias Jhebp29) reduces the mean lifespan, where the reduction in males is slightly higher. The lifespan of females and male flies underexpressed CG3776 is reduced by 31.6% and 38.8%, respectively when compared with Oregon R flies [18275960].. Fly -31.6 to -38.8
    Ilp2 RNAi Ilp2 RNA interference results in a 24% to 47% increase in median lifespan [19005568]. Fly +24 to +47
    Ablation of median neurosecretary cells Flies with an ablation of median neurosecretary cells (which eliminates Ilp2 expression) exhibit a significant increase in mean and maximum lifespan over that of control flies and an increase to oxidative stress and starvation. The mutants also exhibit increased storage of lipid and carbohydrate, reduced fecundity, and reduced tolerance of heat and cold [15708981]. The median and maximum lifespan of females is increased by 33.5% and 40%, respectively. In males the median and maximum lifespan is increased by 10.5% and 27%, respectively [15708981]. Fly +10.5 to +33.5 +27 to +40
    Gr63a mutation Gr63a loss-of-function in female flies leads to 30% extended mean lifespan, increased fat deposition, and enhanced resistance to some (but not all) environmental stresses. Lifespan of males is not extended [20422037]. Fly +30
    esc mutation Males heterozygous for the null esc4 or the dominant negative esc9 mutation that are progeny of an out-cross to a O-R wild-type strain have median lifespan that is, respectively, 47% and 60% longer than the O-R control. When derived from an out-cross to a longer-lived C-S wild-type strain, heterozygous esc9 flies have a median lifespan that is 43% longer than the C-S control [20018689]. Fly +47 to +60 +34
    elav mutation elav mutation significantly decreases the lifespan. Median lifespan in males is 66% lower [20589912]. Fly
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    • 25 of 1193 interventions
    Interventions are an extension of GenAge and GenDR.