• name effect species mean median maximum
    Moderate DR Moderate DR is the restriction of glucose concentration from 2% (*ad libitum*) to 0.5%, which extends the mean, median and maximum replicative lifespan by 45 - 52%, 43 - 50% and 50 - 52%, respectively [23172144] Moderate DR increases vacuolar acidity in young cells and prevents the decline of vacuolar acidity in aging cells. DR also suppresses mitochondrial dysfunciton of aged cells (21 divisions) in a V-ATPase-dependent manner [23172144]. Constitutively activating PKA signaling by deleting the Ras GTPase-activating protein IRA2 reduces vacuolar acidity and accelerates the development of mitochondrial dysfunction in aging cells and prevents DR-mediated enhancement of vacuolar acidity and suppression of mitochondrial dysfunction [23172144]. Lifespan extension by DR is prevented in a strain lacking V-ATPase activity [23172144]. Yeast +45.2 to +51.7 +42.9 to +50.0 +50.0 to +52.0
    Methionine restriction Restriction of the methionine content in the culture extends mean and maximum lifespan by up to 29 and 16% (1/10 methionine content) [15141092]. Yeast +29 +16
    Methionine restriction A diet with reduced methionine content extends lifespan and increases body fat [15924568]. Mouse
    Restriction of yeast Restriction of yeast, the major source of protein in the lfy diet, robustly extends lifespan [15186745; 16000018]. Fly
    Low calorie diet with low-sugar content A diet with low-calorie and low-sugar content increase the lifespan, but not resistance to acute oxiditive stress [22672579] Fly
    High sugar low protein diet A high sugar low protein diet increases the lifespan, but not resistance to acute oxidative stress [22672579]. Fly
    Dietary restriction by 1% yeast medium Dietary restriction by be reducing yeast content in medium to 1% extends the lifespan [19968629]. Fly
    Intermittent fasting Intemittent fasting diet increases survivorship and improves insuli sensitivity of normal males, but fails to affect either parameter in GHRKO mice [19747233]. Mouse
    30% Dietary restriction 30% dietary restriction starting at 2 months of age increases overall, average, median and maximal lifespan. Knockout of Ghr failed to respond with lifespan extension to this regimen [16682650]. Mouse
    Dietary restriction on high-fat diet Dietary restriction on a high-fat diet increases both mean and maximum lifespan by 36% compared to the high-fate diet control group [22509016]. Mouse +36 +36
    Dietary restriction on low-fat diet DR under a low-fat diet increases mean and maximum lifespan by 20% and 25%, respectively [22509016]. Mouse +20 +25
    • 11 interventions
    Interventions are an extension of GenAge and GenDR.