Denigma

Mir20a Overexpression

Species: House mouse (Taxid: 10090)
Factor: MIR20A
Manipulation: Gain-of-Function, Overexpression
Effect:

Overexpression of MiR-20a in mouse embryonic fibroblasts induces senescence by lowering Lrf (a transcriptional repressor of the Mdm2 inhibitor p19ARF [15662416; 9529248]) protein levels and in turn increasing p19ARF levels [18596985].


Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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