Dnmt gene therapy

Species: House mouse (Taxid: 10090)
Factor:
Manipulation: Gain-of-Function, Overexpression
Effect:

Injecting a virus that contains extra copies of a Dnmt into elderly mice restored their faulty memories to it oiriganal capacity of young ones. Halving the amount of Dnmt produced by younger mice, deteriotes their memory to that of non-treated older mice [http://www.medicaldaily.com/news/20120702/10573/aging-memory-dna-enzyme-forgetfulness-young-old.htm].




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