unc-64 mutation

Species: Nematode (Taxid: 6239)
Factor: unc-64
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Mutations in unc-64 result in constitutive dauer formation and increase lifespan, which is suppressed by mutations in daf-16 [10377425]. unc-64 mutation increases mean and maximum lifespan [16280150]. unc-64 mutation increased lifespan of hermaphrodites by approximately 70% and those of males by 150% [10377425; 4366476; 10747056].

unc-64 mutants are uncoordinated [4366476].

Mean: +70 to +150

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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