CKIepsilon mutation

Species: Syrian hamster (Taxid: 10036)
Factor: CKIepsilon
Manipulation: Gain-of-Function, Mutation
Effect:

A mutation in CKIepsilon called tau, if homozygous, shortens the circadian period (by 20%), increases metabolic rate (by 20%), and increases lifespan by 14-16% under conditions of constant darkness [12054192].

Male and female wild-type hamsters are heavier than homozygous mutants throughout the entire lifespan, and heterozygous mutants have intermediate weight [12054192].

Mean: +14 to +16

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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