Denigma

Sirt1 knockout

Species: House mouse (Taxid: 10090)
Factor: Sirt1
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Sirt1 knock-out mouse embryonic fibroblasts (MEFs) have a significant greater replicative capacity in culture. p19ARF levels are significantly reduced in Sirt1 knock-out MEFs [16054100].

Sirt1-null mice do not exhibit lifespan extension upon Dietary Restriction [18335035].


References:
  • 16054100: Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress.
  • 18335035: SirT1 regulates energy metabolism and response to caloric restriction in mice.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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