RAD52 deletion

Species: Budding yeast (Taxid: 4932)
Factor: RAD52
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Deletion in RAD52 causes a 75% reduction in mean replicative lifespan in PSY316 strain [10207108]. Similiar reduction of lifespan occurs in strains W3031-A and W303R [M. Baeberlein, M. McVey, and L. Guarente, unpublished].

RAD51 is required for formation of extrachromosomal rDNA circles [10207108], but not for replication fork pasuing nor DNA breakage with the rDNA [10693764].

Mean: -75

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR
  • Comparisons:
  • rad52 vs. wild-type ( 30°C ) : -55.4(mean) 43.5(median) -80.4(max)



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