Denigma

pgl-1 mutation

Species: Nematode (Taxid: 6239)
Factor: pgl-1
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

pgl-1(bn101) mutant animals that are sterile have a approximately 35% longer lifespan. In contrast, fertile pgl-1(bn101) animals have a wild-type lifespan [11799246].

PGL-1 is required for fertility and proliferation of germ line cells [9741628].

Mean: +35

References:
  • 11799246: Regulation of life-span by germ-line stem cells in Caenorhabditis elegans.
  • 9741628: PGL-1, a predicted RNA-binding component of germ granules, is essential for fertility in C. elegans.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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