Denigma

nuc-1 RNAi

Species: Nematode (Taxid: 6239)
Factor: nuc-1
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

RNA interference of nuc-1 extends mean lifespan by 30%. nuc-1 is differentially transcribed in daf-16 and daf-2 RNAi animals [12845331].

nuc-1 null mutants display reduced fertility [11861554].

Mean: +30

References:
  • 12845331: Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans.
  • 11861554: Roles for Caenorhabditis elegans rad-51 in meiosis and in resistance to ionizing radiation during development.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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