Denigma

Rapamycin treatment

Species: Budding yeast (Taxid: 4932)
Factor: Rapa
Manipulation: Diet Intervention, Drug treatment
Effect:

Treatment with rapamcyin increases mean and maximum replicative lifespan by 19 and 16% Rapamycin fails to extend the lifespan of sir2 mutants or NAM treated wild-type cells [20947565]. Rapamcyin treatment increases mean chronological lifespan by by approximately by 80% in BY4742 [22790951].

Rapamycin extends chronological lifespan proportional with increasing concentrations from 100 pg/mL to 1 ng/mL [16418483]

Mean: +19 to +50
Maximum: +16

References:
  • 20947565: Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae.
  • 22790951: New rapid screening method for anti-aging compounds using budding yeast and identification of beauveriolide I as a potent active compound.
  • 16418483: Extension of chronological life span in yeast by decreased TOR pathway signaling.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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