Denigma: Intervention

Eip71CD overexpression

Species: Fruit fly (Taxid: 7227)
Factor: Eip71CD
Manipulation: Gain-of-Function, Overexpression
Effect:

Overexpression of Eip71CD (alias MsrA) in nervous system extends the lifespan by up to 70%, increases resistance to oxidative stress, and delays the onset of senescence-induced decline in activity levels and reproductive capacity. Eip71CD is a downstream effector of foxo [22310715].

Mean and maximum lifespan is increased by up to 2-% in animals that overexpress Eip71CD [20655917].

Mean: +20 to 70
Maximum: +20

References:

22310715: Methionine sulfoxide reductase B in the endoplasmic reticulum is critical for stress resistance and aging in Drosophila.

20655917: The Drosophila homolog of methionine sulfoxide reductase A extends lifespan and increases nuclear localization of FOXO.

Aging Relevance Analysis/Source:

GenAge