Denigma: Intervention

NCA3 deletion

Species: Budding yeast (Taxid: 4932)
Factor: NCA3
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Disruption in NCA3 shortens mean (87% of normal), nut not maximum replicative lifespan without causing any other gross changes in cell cycle parameters of growth characteristics [8810036].

In combination with an NCA2 disruption, NCA3 disruption causes a cryosensitive phenotype on non-fermentable carbon sources due to a defect in the F1-F0 ATP synthetase due to misbalancing of alternate spliceforms of mitochondrial mRNA encoding subunits 6 and 8 of the synthase [7586026].

Mean: -87

References:

8810036: Review: to bud until death: the genetics of ageing in the yeast, Saccharomyces.

7586026: NCA3, a nuclear gene involved in the mitochondrial expression of subunits 6 and 8 of the Fo-F1 ATP synthase of S. cerevisiae.

Aging Relevance Analysis/Source:

GenAge