Denigma

MPT5 overexpression

Species: Budding yeast (Taxid: 4932)
Factor: MPT5
Manipulation: Gain-of-Function, Overexpression
Effect:

Overexpression of MPT5 from the ADH promoter extends replicative lifespan by about 20% in W303R [11805047] and by 25% in PSY142 [9150138].

MPT5 overexpression suppresses the temperature phenotype of POP2 mutant [9504907].

Mean: +20 to +25

References:
  • 11805047: Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity.
  • 9150138: Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.
  • 9504907: Dhh1p, a putative RNA helicase, associates with the general transcription factors Pop2p and Ccr4p from Saccharomyces cerevisiae.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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