Denigma: Intervention

mev-1 mutation

Species: Nematode (Taxid: 6239)
Factor: mev-1
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Loss of function in mev-1 shortens lifespan to 66% of wild-type (i.e. by 34%) and accelerates accumulation of aging-associated biomarkers such as protein carboynls and fluorescent materials. mev-1 mutants are hypersensitive to raised oxygen concentrations and their lifespan decreases dramatically as oxygen concentrations increase [9716135]. Mutation of mev-1 results in paraquat sensitivity, slow grows, and low fecundity. mev-1 mutants have a 50% reduction in superoxide dismutase activt relatively to wild-type [2233820].

References:

9716135: A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes.

2233820: A methyl viologen-sensitive mutant of the nematode Caenorhabditis elegans.

Aging Relevance Analysis/Source:

GenAge