LAC1 deletion

Species: Budding yeast (Taxid: 4932)
Factor:
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Deletion of LAC1 the homolog of LAG1 [9872981] has no effect on replicative lifespan in strain W303R and PSY316 [N. Bishop, G. Liszt, and L. Guarente, unpublished]. LAC1 null mutant has no obvious growth defect [10198056], but is synthetically lethal with LAG1 mutation [9872981].


References:
  • 10198056: Two endoplasmic reticulum (ER) membrane proteins that facilitate ER-to-Golgi transport of glycosylphosphatidylinositol-anchored proteins.
  • 9872981: Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human.




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