isp-1 mutation

Species: Nematode (Taxid: 6239)
Factor: isp-1
Manipulation: Loss-of-Function, Mutation, Missense

A missense mutation in isp-1 leads to low oxygen consumption, decreased sensitivity to reactive oxygen species, and increased mean (60%) and maximum (100%) lifespan. An isp-1;daf-2 double mutant has a lifespan that is longer than either single mutant, but the lifespan extension of the double mutant is not addative relative to each single mutant [11709184].

Mean: +60
Maximum: +100

  • 11709184: Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans.

  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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