InRE19/InRp5545 transheterozygous mutation

Species: Fruit fly (Taxid: 7227)
Factor: InR
Manipulation: Loss-of-Function, Mutation
Effect:

Mutations in InR (InRE19/InRp5545 transheterozygous) result in dwarf females with extended lifespan of up to 85% and dwarf males with reduced late age-specific mortality (although no significant change in lifespan) [11292875].

Mean: +85

References:
  • 11292875: A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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