Denigma

TXN overexpression

Species: House mouse (Taxid: 10090)
Factor: TXN
Manipulation: Gain-of-Function, Overexpression
Effect:

Overexpression of TXN1 in transgenic C57BL/6 mice resulted in extended median (35%) and maximum (22%) lifespan. Telomerase activity in spleen tissues of TXN1 overexpressing mice is higher than tha in wild-type [12230882].

Median: +35
Maximum: +22

References:
  • 12230882: Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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