TERT overexpression

Species: Human (Taxid: 9606)
Factor: TERT
Manipulation:
Effect:

Telomerase-expressing cells (human foreskin fibroblasts, retinal pigment epithelial cells) maintain normal length of telomeres and continue to divide vigorously [9454332]. Cells expression telomerase have reduced staining for beta-galactosidase (a biomarker of cellular senescence) [9501072]. TERT expression is also able to prevent the accelerated replicative senescence observed in cells taken from Werner's patients [10615119].


References:
  • 9454332: Extension of life-span by introduction of telomerase into normal human cells.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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