Denigma

HSP104 overexpression

Species: Budding yeast (Taxid: 4932)
Factor: HSP104
Manipulation: Gain-of-Function, Overexpression
Effect:

Overexpression of HSP104 driven by GAL promoter is insufficient to extend replicative lifespan [9851879]. Overproduction of HSP104 in wild-type cells has no effect on replicative life span, but suppresses the reduced lifespan of Sir2-deficient cells [17908928]. HSP104 overproduction is sufficient to induce thermotolerance [8643570].


References:
  • 17908928: Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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