hsf-1 RNAi

Species: Nematode (Taxid: 6239)
Factor: hsf-1
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

hsf-1 RNAi abrogates lifespan extension by daf-2(e1370) mutation, but not eat-2(ad1116) or isp-1(qm150). HSF-1, like DAF-16, is required for daf-2 mutations to extend lifespan [12750521]. RNA interference of hsf-1 suppresses normal dauer formation and life-extension due to insulin-like signaling [14668486]. hsf-1 RNAi also prevents lifespan extension by bDR. bDR significantly reduces paralysis of Q35YFP or ABeta42 transgenic animals and hsf-1 RNAi totally cancels this effect. hsf-1 RNAi attenuates lifespan extension by bDR, but only partially that of daf-2 mutation. hsf-1 RNAi attenuates protection against oxidative stress by bDR. hsf-1 expression is induced by bDR [19924292]. RNAi of hsf-1 shortens median and maximum lifespan by approximately 35%. hsf-1 RNAi animals exhibit phenotypes associated with accelerated aging (as assyed by Nomarsky microscopy) [12136014].

Median: -35
Maximum: -35

References:
  • 19924292: Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling.
  • 12136014: Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation.
  • 14668486: Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR
  • Comparisons:
  • hsf-1 RNAi vs. control : -45.7(mean) <0.0001(p-value)
  • hsf-1 RNAi vs. control : -42.2(mean) <0.0001(p-value)



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