Denigma: Intervention

SRS2 deletion

Species: Budding yeast (Taxid: 4932)
Factor: SRS2
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Deletion of SRS2 shortens mean replicative lifespan by 50% [11290710]. Overexpression of SGS1 increases maximum, but not mean lifespan of SRS2 mutants [11861900]. Deletion of SRS2 is synthetical lethal in combination with deletion of SGS1 [11290710].

Mean: -50

References:

11861900: SGS1 is a multicopy suppressor of srs2: functional overlap between DNA helicases.

11290710: The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination.

Aging Relevance Analysis/Source:

GenAge