Denigma: Intervention

HDA1 deletion

Species: Budding yeast (Taxid: 4932)
Factor: HDA1
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Deletion of HDA1 has no effect on longevity under AL, but acts synergistically with 0.1% glucose restriction to increase replicative lifespan [12213553]. Deletion of HDA1 leads to a slightly increased chronological lifespan [19801973]. Deletion of HDA1 has no effect on the wild-type lifespan in the short-lifespan of YSK771 strain, but suppresses the short-lifespan of SIR3 mutants [10512855]. Null mutation results in increased telomeric silencing and increased histone acetylation [8962081].

References:

19801973: Induction of autophagy by spermidine promotes longevity.

12213553: Distinct roles of processes modulated by histone deacetylases Rpd3p, Hda1p, and Sir2p in life extension by caloric restriction in yeast.

10512855: Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae.

8962081: HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription.

Aging Relevance Analysis/Source:

GenAge