Denigma

GPA2 deletion

Species: Budding yeast (Taxid: 4932)
Factor: GPA2
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Deletion of GPA2 increases mean and maximum replicative lifespan by 40% and 26%, respectively. GPA2 deletion extends replicative lifespan by reducing cAMP-PKA activity and provides a genetic model for DR [11000115].

Mean: +40
Maximum: +26

References:
  • 11000115: Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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