Denigma

Homozygous GH1 deletion

Species: Human (Taxid: 9606)
Factor: GH1
Manipulation: Loss-of-Function, Mutation, Deletion
Effect:

Mean lifespan in untreated, affected individuals homozyogus for a deletion at the GH1 locus is significantly shorter (P < 0.05) than in affected siblings or the general population. Individuals homozygous for GH1 deletion demonstrate hereditary dwarfism [12915652].


References:
  • 12915652: Reduced longevity in untreated patients with isolated growth hormone deficiency.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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