p53 deletion mutation

Species: House mouse (Taxid: 10090)
Factor: Trp53
Manipulation: Loss-of-Function, Mutation, Deletion
Effect:

Mice heterozyogous for an allele of p53 that removes the 5' portion of the protein demonstrate decreased cancer, permature aging phenotypes, and shortened lifespan [11780111].


References:
  • 11780111: p53 mutant mice that display early ageing-associated phenotypes.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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