Denigma

p53 mutation

Species: Fruit fly (Taxid: 7227)
Factor: p53
Manipulation: Loss-of-Function, Mutation
Effect:

Globally lack of p53 decreases lifespan [16303568]. Loss of p53 activity slightly shortens the lifespan. Mutants that lack p53 survive well up to 50 days, but mortality rate increases relative to wild-type at later ages. p53 mutant animals are extremely sensitive to irradiation [12935877].


References:
  • 16303568: Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span.
  • 12935877: In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in Drosophila.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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