Denigma: Intervention

daf-18 mutation

Species: Nematode (Taxid: 6239)
Factor: daf-18
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

daf-18 is required for complete dauer formation. daf-18 mutation partially suppresses the lifespan extension of age-1 and daf-2 mutants. daf-18 mutants are defective for dauer formation and form some dauer-like larvae when starved [7789761; 8601482].

References:

7789761: Genes that regulate both development and longevity in Caenorhabditis elegans.

8601482: The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.

Aging Relevance Analysis/Source:

GenAge