Denigma

Ghrhr knockout

Species: House mouse (Taxid: 10090)
Factor: Ghrhr
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Homozygosity for the Ghrhr(lit) knockout mutation (called little mouse) lowers plasma growth hormone levels, impairs growth and increases lonegevity about 20% [11371619]. Lit homozygous animals are smaller than normal mice [1270792] and their pituitary is defective in growth hormone and prolactin [978118].

Mean: +20

References:
  • 11371619: Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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