Pou1f1 knockout

Species: House mouse (Taxid: 10090)
Factor: Pou1f1
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Snell dwarf mutation (Pit1dw) due to knockout of Pou1f1 results in a dramatic lifespan extension. The mean, median and maximum lifespan is increased by 40-50% for Snell dwarf (Pit1dw/Pit1dw) DW/J females, and 25-50% for dwarf DWC3F1 males and females with a compound heterozygous Pit1dw/Pit1dw-J genotype. Although, Snell dwarf (Pit1dw/Pit1dw) DW/J males exhibit aspects of delayed senescence, their median lifespan is by about 25% shorter, probably due to the affects of housing conditions [11718806]. Mice homozygous for loss-of-function mutations at Pit1 locus have a mean and maximum lifespan extension over 40%. Mutant dwJ/dw animals exhibit delays in age-dependent collagen cross-linking and in six age-senstive indices of immune system status. Pituitary transplantation into dwarf mice does not reverse the lifespan extension effect. Male Snell dwarf mice become obese and exhibit proportionately high leptin levels in old age [11371619].

Mean: +25 to +50
Median: +25 to +50
Maximum: +25 to +50

References:

11718806: The Snell dwarf mutation Pit1(dw) can increase life span in mice.

11371619: Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production.

Aging Relevance Analysis/Source:

GenAge

GenDR

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