Denigma

CDC6 mutation

Species: Budding yeast (Taxid: 4932)
Factor: CDC6
Manipulation: Loss-of-Function, Knockdown, Mutation
Effect:

The CDC6-1 conditional allele results in an approximately 20% increase in mean replicative life span. This allele is defective for replicative initiation form the rDNA ARS at 27 degree Celsius, resulting in a reduced rate of extrachromosomal rDNA circle accumulation [9428525]. The cdc6-1 allele results in genomic instability at the permissive temperature [8552037].

Mean: +20

References:
  • 9428525: Extrachromosomal rDNA circles--a cause of aging in yeast.
  • 8552037: The genomic instability of yeast cdc6-1/cdc6-1 mutants involves chromosome structure and recombination.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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