CCR4 deletion

Species: Budding yeast (Taxid: 4932)
Factor: CCR4
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Deletion of CCR4 increases mean chronological lifespan by 20 - 41% (20, 33, 41) in diploid cells [21447998]. In W303R CCR4 deletion shortens replicative lifespan by approximately 80% and results in temperature sensitivity that is suppressed by SSD1-V. SSD1-V partially suppresses the short-lifespan of ccr4 mutant. CCR4 mutation is synthetically lethal in combination with deletion of MPT5 in the absence of SSD1-V [11805047].

Mean: -80 to +20

References:
  • 21447998: A genomic analysis of chronological longevity factors in budding yeast.
  • 11805047: Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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