Denigma: Intervention

Sod overexpression

Species: Fruit fly (Taxid: 7227)
Factor: Sod1
Manipulation: Gain-of-Function, Overexpression
Effect:

Simultaneous overexpression of catalase and Sod (alias Sod1) results in a one-third lifespan extension, a slower rate of mortality acceleration, and a delayed loss in physical performance, but neither has any effect on lifespan alone [8108730]. General overexpression of Sod (also known as Cu/ZnSOD) alone is sufficient to extend lifespan by up to 48%. Simultaneous overexpression of catalase with Cu/ZnSOD has no added benefit, presumably due to a pre-existing excess of catalase [9858546].

Mean: +38

References:

8108730: Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.

9858546: FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies.

Aging Relevance Analysis/Source:

GenAge