Replacement of Cebpa by Cebpb

Species: House mouse (Taxid: 10090)
Factor: Cebpb Cebpa
Manipulation: Gain-of-Function, Loss-of-Function, Mutation, Replacement
Effect:

Replacing the Cebpa gene by Cebpb increases mean lifespan by about 20% [15289464]. C/ebpalpha(beta/beta) animals consume more food but weight less than controls [10982846], and have a slightly elevated body temperature (0.3-0.5 degree Celsius) [15289464].

Mean: +20

References:
  • 15289464: Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells.
  • 10982846: C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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