bchs mutation

Species: Fruit fly (Taxid: 7227)
Factor: bchs
Manipulation: Loss-of-Function, Mutation

Loss of function mutation in bchs results in a 40-45% decrease in mean lifespan and is associated with age-related neurodegenerative phenotype with reduced CNS size and altered morphology as well as accumulation of insoluble ubiquinated proteins and amyloid precursor-like proteins along with an increase in neuronal apoptosis. No pronounced developmental defects were observed and young adults have normal behaviours, indicating that the bchs gene is essential for normal adult survival and longevity [12598614].

bchs mutation reduces mean lifespan by 28 - 54% and maximum lifespan by 24 - 46% [17435236].

Mean: -28 to -54
Maximum: -24 to -46

  • 12598614: blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration.
  • 17435236: Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles.

  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR
  • Comparisons:
  • bchs/df clot vs. Canton-S ( 25°C male ) : -53.7(mean) -32.4(max) <0.0001(p-value)
  • bchs/bchs vs. Canton-S ( 25°C male ) : -49.4(mean) -45.6(max) <0.0001(p-value)
  • bchs/bchs vs. white1118 ( 29°C male ) : -44.3(mean) -37.9(max) <0.0001(p-value)
  • bchs/Df(2L)clot7 vs. white1118 ( 29°C male ) : -38.3(mean) -44.8(max) <0.0001(p-value)
  • bchs (EP2299) vs. white1118 ( 29°C male ) : -28.2(mean) -24.1(max) <0.0001(p-value)

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