Wortmannin treatment

Species: Fruit fly (Taxid: 7227)
Factor:
Manipulation: Diet Intervention, Drug treatment
Effect:

Treatment of Drosophila imago with 0.5 micromolar wortmannin increases median (by 5%) and maximum (by 39%) lifespan in males (p < 0.001), but the lifespan differences in females were statistical insignificant (p > 0.05) [22661237].

Low dose of wortmannin (5 microM) slightly increase the median and maximum lifespan [20017609].

Median: +5
Maximum: +39

References:
  • 22661237: The second international conference "genetics of aging and longevity".
  • 20017609: Pharmacological inhibition of phosphoinositide 3 and TOR kinases improves survival of Drosophila melanogaster.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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